CatalogNo.: S-100F MW: 672.81 Description: Echelonoffersauniqueselectionofsphingosineanalogslabeledattheterminusofthealkylchainwithbiotinorfluorescentgroups.Allcompoundsaresynthesizedfromchiralprecursorsandareavailableaslyophilizedpowders. Echelon'salkyl-labeledsphingosinesaresynthesizedwiththenaturalerythrostereochemistryandmaintainsimilarpropertiesassphingosine.Forexample,labeledsphingosinesarephosphorylatedbysphingosinekinases(1&2)andcanbeusedinhighthroughputscreeningapplications.Inaddition,theyinduceaNiemanPicktypeC1diseasecellularphenoypeinRAWmacrophagesinthesamemannerasexogenouslyaddedsphingosine. | ||||
StorageSphingosinefluoresceinisrelativelystableatroomtemperatureasasolid.Itisbeststoredasadriedsolid,protectedfromlightat-20ºC.Solutions/emulsionsshouldbekeptat-20ºC.Excitation/Emission494/521nmFeaturedinPublications1)Lloyd-Evans,E.,A.J.Morgan,etal.(2008)."Niemann-PickdiseasetypeC1isasphingosinestoragediseasethatcausesderegulationoflysosomalcalcium."NatMed14(11):1247.2)Xiang,Y.,G.Asmussen,etal.(2009)."Discoveryofnovelsphingosinekinase1inhibitors."BioorgMedChemLett19(21):6119-21. 3)CaliperLifeSciencesApplicationNote205 4)Peest,U.,S.C.Sensken,etal.(2008)."S1P-lyaseindependentclearanceofextracellularsphingosine1-phosphateafterdephosphorylationandcellularuptake."JCellBiochem104(3):756-72. 5)Meissner,A.,J.Yang,etal.(2012)."TumorNecrosisFactor-α-MediatedDownregulationoftheCysticFibrosisTransmembraneConductanceRegulatorDrivesPathologicalSphingosine-1-PhosphateSignalinginaMouseModelofHeartFailure."Circulation125(22):2739-2750. SolubilityMeOH>1mg/ml |
产品名 | 货号 | 公司分类 | 分类 | 美金价 |
Viskase/透析袋 MD25(3500)/25mm/MD25-3.5 | MD25-3.5 | 透析 | 透析 | 1543.14 | 指尖陀螺 | 1221 | 常用设备 | 4.50 |