CatalogNo.: E-5000L Description: Sphingsoine-1-phosphatelyase(SPL)(E.C.4.1.2.27)worksasakeyregulatorofthefinalstepofthesphingolipiddegradativepathwaybyirreversIBLybreakingdownthesphingosine-1-phosphate(S1P)toethanolaminephosphateandhexadecenal.S1PsignalingthroughitsfivereceptorsinvolvesinmanyBIOLOGicaleventssuchasproliferation,inflammationandapoptosisincancerandotherdegenerativediseases. | |||
HEK293celllysatewithoverexpressedSPL-GFP(greenfluorescentprotein). Storage-80°C.Theenzymeisstablefor6monthsfromthedateofreceipt.Avoidrepeatfreezethawcycles.References1.Billich,A.,etal.(2013)."Partialdeficiencyofsphingosine-1-phosphatelyaseconfersprotectioninexperimentalautoimmuneencephalomyelitis."PLoSOne8(3):e59630.2.Engel,N.,etal.(2012)."Metabolicprofilingrevealssphingosine-1-phosphatekinase2andlyaseaskeytargetsof(phyto-)estrogenactioninthebreastcancercelllineMCF-7andnotinMCF-12A."PLoSOne7(10):e47833. 3.Bedia,C.,etal.(2009)."Synthesisofafluorogenicanalogueofsphingosine-1-phosphateanditsusetodeterminesphingosine-1-phosphatelyaseactivity."Chembiochem10(5):820-2. 4.Reiss,U.,etal.(2004)"Sphingosine-phosphateLyaseEnhancesStress-inducedCeramideGenerationandApoptosis."J.Biol.Chem.279(2):1281-1290. Relatedproducts Sphingosine-1-PhosphateLyaseFluorogenicSubstrate(S-200U) 2-Acetyl-5-tetrahydroxybutylimidazole(THI)(B-0031) Sphingolipids Sphingosine1-PhosphateELISAkit(K-1900) |
产品名 | 货号 | 公司分类 | 分类 | 美金价 |
Viskase/透析袋 MD25(3500)/25mm/MD25-3.5 | MD25-3.5 | 透析 | 透析 | 1543.14 | 指尖陀螺 | 1221 | 常用设备 | 4.50 |