ScientificBackground- Akt3orProteinKinaseBã(PKBã)isaserine/threoninekinasethatisamemberoftheAktfamily.Inmammals,theAktfamilycomprisesofthreehighlyhomologousmembersknownasAkt1(PKB),Akt2(PKB),andAkt3(PKB).Akt3liketheotherfamilymembersisactivatedincellsexposedtodiversestimulisuchashormones,growthfactors,andextracellularmatrixcomponents.Theactivationmechanismremainstobefullycharacterizedbutoccursdownstreamofphosphoinositide3-kinase(PI3K).PI3Kgeneratesphosphatidylinositol-3,4,5-trisphosphate(PIP3),alipidsecondmessengeressentialforthetranslocationofAktfamilymemberstotheplasmamembranewheretheyarephosphorylatedandactivatedbyphosphoinositide-dependentkinase-1(PDK-1)andphosphoinositide-dependentkinase-2(PDK-2possIBLyILK).Akt3liketheotherfamilymembersphosphorylatesandregulatesthefunctionofmanycellularproteinsinvolvedinprocessesthatincludecellularmetabolism,survival/apoptosis,andproliferation.Rec
Storage- Storeproductfrozenatorbelow-70°C.Stablefor1yearat-70°Casundilutedstock.Aliquottoavoidrepeatedthawingandfreezing.
产品名 | 货号 | 公司分类 | 分类 | 美金价 | Viskase/透析袋 MD25(3500)/25mm/MD25-3.5 | MD25-3.5 | 透析 | 透析 | 1543.14 | 指尖陀螺 | 1221 | | 常用设备 | 4.50 |
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