ScientificBackground- MostoftheeffectsofcAMParemediatedthroughthephosphorylationoftargetproteinsonserineorthreonineresiduesbythecAMP-dependentproteinkinase(AMPK).TheinactiveholoenzymeofAMPKisatetramercomposedoftworegulatoryandtwocatalyticsubunits.ThemammaliancatalyticsubunithasbeenshowntoconsistofthreePKAgeneproducts:C-alpha,C-beta,andC-gamma.TwoPKAisoformsexist,designatedtypesIandII,whichdifferintheirdimericregulatorysubunits,designatedRIandRII,respectively.FurThermore,thereareatleastfourdifferentregulatorysubunits:RI-alpha,RI-beta,RII-alpha,andRII-beta.ThecAMPcausesthedissociationoftheinactiveholoenzymeintoadimerofregulatorysubunitsboundtofourcAMPandtwofreemonomericcatalyticsubunits.ThecatalyticsubunitC-betaofPKA(PKAcb)isamemberoftheSer/ThrproteinkinasefamilyandisacatalyticsubunitC-betaofAMPK.Berubeetal.assignedthePKAcbtohumanchromosome1bySouthernblotanalysisofsomaticc
Storage- Storeproductfrozenatorbelow-70°C.Stablefor1yearat-70°Casundilutedstock.Aliquottoavoidrepeatedthawingandfreezing.
References- 1.Berube,D.;Simard,J.;Sandberg,M.;Grzeschik,K.-H.;Gagne,R.;Hansson,V.;Jahnsen,T.:AssignmentofthegeneencodingthecatalyticsubunitC(beta)ofcAMP-dependentproteinkinasetothep36bandonchromosome1.(Abstract)Cytogenet.CellGenet.58:1850only,1991.2.Simard,J.;Berube,D.;Sandberg,M.;Grzeschik,K.-H.;Gagne,R.;Hansson,V.;Jahnsen,T.:AssignmentofthegeneencodingthecatalyticsubunitC-betaofcAMP-dependentproteinkinasetothep36bandonchromosome1.Hum.Genet.88:653-657,1992.
产品名 | 货号 | 公司分类 | 分类 | 美金价 | Viskase/透析袋 MD25(3500)/25mm/MD25-3.5 | MD25-3.5 | 透析 | 透析 | 1543.14 | 指尖陀螺 | 1221 | | 常用设备 | 4.50 |
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