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实验室透析袋
℡ 4000-520-616
℡ 4000-520-616
echelon-inc/Src, active/5ug/E-K051-5ug
产品编号:E-K051-5ug
市  场 价:¥5260.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$263.00
品      牌: Echelon
公      司:VISKASE
公司分类:
echelon-inc/Src, active/5ug/E-K051-5ug
商品介绍

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CatalogNo.: E-K051

Description: RecombinantfulllengthRoussarcomavirusSrcproteincontainingN-terminalGSTtagwasexpressedbybaculovirusinSf9insectcells.
ThegeneaccessionnumberisM11753.
Thismaterialissoldforresearchpurposesonly.
SpecificActivity
116nmolphosphateincorporatedintoSrcsubstratepeptideperminutepermgproteinsat300Cfor15minutesusingafinalconcentrationof50µMATP(0.83µCi/assayin25ulreactionvolume).

ScientificBackground

  • Srcfamilybelongstonon-receptortyrosinekinases.SrcwasoriginallyidentifiedasatransformingproteinoftheRoussarcomavirus(RSV)thathadenzymaticABIlitytophosphorylatetyrosineinproteinsubstrates.Srcisoverexpressedandactivatedinalargenumberofhumanmalignanciesandhasbeenlinkedtothedevelopmentofcancerandprogressiontodistantmetastases.Inadditiontoincreasingcellproliferation,akeyroleofSrcincancerseemstobetheabilitytopromoteinvasionandmotility,functionsthatmightcontributetotumourprogression.OncogenicformsoftheSrcaltercellstructure,inparticulartheactinCytoskeletonandtheadhesionnetworksthatcontrolcellmigration,andalsotransmitsignalsthatregulateproliferationandcellsurvival.RecentworkindicatesthatSrcplaysaroleinthesefunctionsbyinfluencingtheRhoA-ROCKpathwaythatcontrolscontractileactinfilamentassembly,theSTATfamilyoftranscriptionfactorsneededfortransformation,andtheCblubiquiti

    Storage

    • Storeproductfrozenatorbelow-70°C.Stablefor1yearat-70°Casundilutedstock.Aliquottoavoidrepeatedthawingandfreezing.
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