CatalogNo.: B-0101 MW: 381.7 Purity: 99% CAS: 902779-59-3 Description: FPA-124isacell-permeableinhibitorofAkt(IC50=100nM),bindingtothePHandkinasedomains.ItinhibitscellproliferationinColo357,BxPC3,BT20,andPC3cancercelllineswithIC50valuesrangingfrom7-55nM.FPA-124inhibitedtumorgrowthinmicewithnegligIBLetoxicity. | |||
SolubilityDMSO:5mg/mLStorageStoredrybetween2-8oC.Stocksolutionsshouldbestoredfrozen(-20oC).References1)V.Barve,etal.“Synthesis,MolecularCharacterization,andBIOLOGicalActivityofNovelSyntheticDerivativesofChromen-4-oneinHumanCancerCells”J.Med.Chem.,2006,49,3800-3808. 2)Biscetti,F.,G.Straface,etal.(2009)."PioglitazoneenhancescollateralbloodflowinischemichindlimbofdiabeticmicethroughanAkt-dependentVEGF-mediatedmechanism,regardlessofPPARgammastimulation."CardiovascDiabetol8:49. 3)Brito,P.M.,R.l.Devillard,etal.(2009)."ResveratrolinhibitsthemTORmitogenicsignalingevokedbyoxidizedLDLinsmoothmusclecells."Atherosclerosis205(1):126. |
产品名 | 货号 | 公司分类 | 分类 | 美金价 |
Viskase/透析袋 MD25(3500)/25mm/MD25-3.5 | MD25-3.5 | 透析 | 透析 | 1543.14 | 指尖陀螺 | 1221 | 常用设备 | 4.50 |