CatalogNo.: K-5600 Description: Description:Echelon'sATXSandwichELISAisaquantitativeimmunoassaydesignedforinvitromeasurementofATXlevelsincellculturesupernatantorhumanandmouseBIOLOGicalfluids. SampleVolume:5μL SampleNumber:40samples(induplicate)/96-wellassay SampleType:CurrentlythiskithasbeentestedforthequantificationofATXlevelsincellculturesupernatant,sera,plasma,urineandovarianascites. | |||
ProductBackground:Autotaxin,alsoknownasATX,ENPP2,lysophospholipaseD(lysoPLD),phosphodiesterase1αandplasmacellglycoprotein-1,isasecretedglycoproteinthatiswidelyexpressedwithhighlevelsintheserum.ViaitslysoPLDactivity,autotaxinhydrolyzeslysophosphatidylcholine(LPC)togeneratethephospholipidgrowthfactorlysophosphatidicacid(LPA).Theenzyme’ssameactivityhydrolyzessphingosylphosphorylcholine(SPC)toformsphinosine-1-phosphate(S1P).Autotaxinwasfirstisolatedastheautocrinemotilityfactorsecretedfrommelanomacells.Atthattime,theenzyme’slysoPLDactivityhadnotbeenidentified,soitwasclassifiedbyhomologytotheecto-nucleotidepyrophosphatase/phosphodiesterase(NPP)familyofenzymeswhosemembershydrolyzephosphodiesterbondsinvariousnucleotidesandnucleotidederivatives.Itwasinitiallyunclearhownucleotidehydrolysiscouldleadtothestimulationofcellmotility.ThismysterywassolvedwhenautotaxinwasdiscoveredtobeidenticaltoserumlysoPLD.Sincethen,thecancer-relatedactivitiesofautotaxin,atleastinculturedcells,havebeenattributedtotheenzyme’slysoPLDactivity.Inadditiontocancer,autotaxinhasbeenimplicatedinanumberofdiseasesincludingobesity,arthritis,multiplesclerosis,Alzheimer’sdiseaseandneuropathicpain. |
产品名 | 货号 | 公司分类 | 分类 | 美金价 |
Viskase/透析袋 MD25(3500)/25mm/MD25-3.5 | MD25-3.5 | 透析 | 透析 | 1543.14 | 指尖陀螺 | 1221 | 常用设备 | 4.50 |